等渗盐水洗鼻对治疗和预防儿童鼻粘膜炎症的效果 阿里巴巴 z200868的博客 BLOG

等渗盐水洗鼻对治疗和预防儿童鼻粘膜炎症的效果 (2009/07/23 10:42)
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Efficacy of isotonic nasal wash  in the treatment and prevention of rhinitis in children.
等渗盐水洗鼻对治疗和预防儿童鼻粘膜炎症的效果
Slapak I,Skoupá J,Strnad P,Horník P.
Pediatric Otorhinolaryngology Clinic, Teaching Hospital Brno, Czech Republic.
捷克布尔诺教学医院儿童耳鼻喉科临床中心
OBJECTIVE: To evaluate the potential of nasal isotonic saline application to prevent reappearance of cold and flu in children during the winter.
目的：对冬季使用等渗盐水清洗鼻腔控制儿童感冒 症状的效果进行评估。
DESIGN: Prospective, multicenter, parallel-group, open, and randomized comparison.
研究设计：前瞻性，多中心，平行设组，开放，随机对照
SETTING: Eight pediatric outpatient clinics.
参与机构：8所儿科门诊部。
PATIENTS: A total of 401 children (aged 6-10 years) with uncomplicated cold or flu.
病人来源：总计401位6-10岁单纯患感冒或流感的儿童。
INTERVENTIONS: We randomly assigned patients to 2 treatment groups, one with just standard medication, the other with nasal wash with isotonic saline (Physiomer) plus standard medication, and observed them for 12 weeks.
干预措施：我们随机将患者分成2组，一组采用标准的药物治疗方案，另一组是等渗盐水洗鼻加标准的药物治疗，观察时间为12周。
MAIN OUTCOME MEASURES: The primary efficacy end points were nasal symptoms resolution during acute illness (visits 1 and 2). We also looked for reappearance of cold or flu, consumption of medication, complications, days off school, and reported days of illness during the following weeks when preventive potential was evaluated (visits 3 and 4).
主要结果：急性期的鼻部症状得到缓解作为本组研究有效的观察终点（随访组1和2）。我们收集的数据还包括：感冒和流感复发的病例、药品支出费用、并发症、病假天数和随访期间采取了预防措施后记录的患病天数（随附组3和4）。
RESULTS: At visit 2, patients in the saline group achieved primary end points (measured on a 4-point numeric scale on which 1 indicated no symptoms and 4, severe symptoms) in the parameters nasal secretion and obstruction (mean scores vs nonsaline group, 1.79 vs 2.10 and 1.25 vs 1.58, respectively) (P < .05 for both)
结果：在随访组2病人使用盐水洗鼻，鼻腔分泌物和堵塞程度设为观察终点（以1-4记分来表示不同程度：1为没症状，4为重症）：平均分值和非盐水组比较为：1.79比2.10和1.25比1.58；（P﹤0.05）。
. During the prevention phase (at visit 3, 8 weeks after study entry) patients in the saline group showed significantly lower scores in sore throat, cough, nasal obstruction, and secretion (P < .05 for all). By visit 3, significantly fewer children in the saline group were using antipyretics (9% vs 33%), nasal decongestants (5% vs 47%), mucolytics (10% vs 37%), and systemic antiinfectives (6% vs 21%) (P < .05 for all). During the same period children in the saline group also reported significantly fewer illness days (31% vs 75%), school absences (17% vs 35%), and complications (8% vs 32%) (P < .05 for all). Similar results were found at the final visit. CONCLUSION: Children in the saline group showed faster resolution of some nasal symptoms during acute illness and less frequent reappearance of rhinitis subsequently.
在干预期间，（随访组3，研究开始后第8周），在盐水组的病人在因喉咙痛、咳嗽、鼻塞和鼻分泌物等症状而得分明显较低，（全部P﹤.05）。在随访组3，盐水洗鼻的孩子使用退热剂（9% vs 33%）,鼻塞解除药（5% vs 47%），粘液溶解剂（10% vs 37%），全身抗菌素（6% vs21%）等明显减少（P值﹤0.5）；同时，盐水组的孩子们：生病天数（31%vs75%），缺课天数（17%vs35%），以及各种并发症（8%vs32%）也明显下降（P﹤.05）。随访的最终结果也与此相似。结论：盐水洗鼻组的儿童，在急性发作期鼻腔症状缓解得更快，随后的复发率也较低。
2008 Jan;134(1):67-74
《耳鼻喉科学-头颈外科》2008 Jan;134(1):67-74