神马文学网Want to live 40% longer? Eat 70% less food
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Want to live 40% longer? Eat 70% less food2007-06-06 11:06:07
BEIJING, June 5 (Xinhuanet) -- For 70 years scientists have known that fruit flies, mice, dogs and other animals on near-starvation diets tended to live up to 40 percent longer than those with better diets, and a recent study now reveals why.
Reseachers at the Salk Institute for Biological Studies in La Jolla, California, have identified a gene in roundworms that directly connects calorie（卡，热量值） restriction to longer lifespan.
Research leader Andrew Dillin said a gene called pha-4 plays a role in gut（n. 剧情, 内容, 内脏, 肚子, 海峡, 勇气 vt. 取出内脏, 毁坏...的内部） development in embryonic worms but in adults is associated with calorie-restricted longevity. Dillin said it is unclear whether similar genes may play a similar role in humans.
"We don‘t know yet whether or not dietary restriction will increase longevity in humans," Dillin said. "There are several people that are actively doing this voluntarily（ad. 自愿地, 以自由意志）."But there is a primate study that‘s going on that‘s around 35 years into it," he added, "and it looks like the primates（n. 灵长目） are going to respond very well to reduced food intake and actually live longer."
Dillin said it usually takes a 50 to 70 percent reduction in normal food intake to yield longer lifespan in animals.
People have three genes very much like the worm‘s pha-4. They are related to glucagon（[化] 高血糖素; 胰高血糖素 [医] 高血糖素）, a pancreatic（a. 胰腺的） hormone that increases blood sugar concentration and maintains the body‘s energy balance, particularly during fasting.
Identifying the worm gene might open the door to drugs that imitate the effects of calorie restriction and could allow people to live longer without following such a severely restrictive diet, the researchers reported the journal Nature.
BEIJING, June 5 (Xinhuanet) -- For 70 years scientists have known that fruit flies, mice, dogs and other animals on near-starvation diets tended to live up to 40 percent longer than those with better diets, and a recent study now reveals why.
Reseachers at the Salk Institute for Biological Studies in La Jolla, California, have identified a gene in roundworms that directly connects calorie（卡，热量值） restriction to longer lifespan.
Research leader Andrew Dillin said a gene called pha-4 plays a role in gut（n. 剧情, 内容, 内脏, 肚子, 海峡, 勇气 vt. 取出内脏, 毁坏...的内部） development in embryonic worms but in adults is associated with calorie-restricted longevity. Dillin said it is unclear whether similar genes may play a similar role in humans.
"We don‘t know yet whether or not dietary restriction will increase longevity in humans," Dillin said. "There are several people that are actively doing this voluntarily（ad. 自愿地, 以自由意志）."But there is a primate study that‘s going on that‘s around 35 years into it," he added, "and it looks like the primates（n. 灵长目） are going to respond very well to reduced food intake and actually live longer."
Dillin said it usually takes a 50 to 70 percent reduction in normal food intake to yield longer lifespan in animals.
People have three genes very much like the worm‘s pha-4. They are related to glucagon（[化] 高血糖素; 胰高血糖素 [医] 高血糖素）, a pancreatic（a. 胰腺的） hormone that increases blood sugar concentration and maintains the body‘s energy balance, particularly during fasting.
Identifying the worm gene might open the door to drugs that imitate the effects of calorie restriction and could allow people to live longer without following such a severely restrictive diet, the researchers reported the journal Nature.
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