CXCL12

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CXCL12

趋化因子CXCL12 又称基质细胞衍生因子-1(SDF-1)是小分子的细胞因子,属于趋化因子蛋白家族。它有两种形式,SDF-1α/CXCL12a和SDF-1β/CXCL12b[1]。趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构。第一第二半胱氨酸残基之间隔着一个介入氨基酸残基。

趋化因子CXCL12对淋巴细胞有强烈的趋化作用并在发育中起重要作用[2]。在胚胎发育中CXCL12引导造血干细胞从胎儿肝脏骨髓的迁徙。CXCL12基因敲除的小鼠常常死于胎中或出生后1小时内[3][4]。SDF-1α/CXCL12a还可以影响神经元的电生理。CXCL12可以在许多组织(包括胸腺,骨髓,脾脏)中表达。

趋化因子CXCL12的受体是CXCR4[5]。但是,最近有人认为CXCL12还可以与CXCR7受体结合[6]

参考文献

  1. ^ De La Luz Sierra et al. Differential processing of stromal-derived factor-1alpha and beta explains functional diversity. Blood 103:2452-2459, 2004.
  2. ^ Bleul et al. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184: 1101-1109, 1996.
  3. ^ Ara et al. Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc. Nat. Acad. Sci. 100: 5319-5323, 2003.
  4. ^ Ma et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Nat. Acad. Sci. 95: 9448-9453, 1998.
  5. ^ Bleul et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382: 829-833, 1996.
  6. ^ Balabanian et al. The chemokine SDF-1/CXCl12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 280:35760-35766, 2005.